Virus-Induced Chaperone-Enriched (VICE) domains form adjacent to nuclear viral replication compartments (RC) during the early stages of HSV-1 infection. Between 2 and 3 hours post infection at a MOI of 10. host protein quality control machinery such as molecular chaperones (e. g. https://www.roneverhart.com/Custom-Enve-Melee-2024-p16044/